GHRP-2 10mg – Growth Hormone Releasing Peptide for Strength
$59.99
GHRP-2 (Growth Hormone Releasing Peptide-2), also known as Pralmorelin or KP-102, is a potent synthetic hexapeptide and a member of the growth hormone secretagogue (GHS) class. It acts as a selective agonist of the ghrelin receptor (GHS-R1a), mimicking the action of the natural “hunger hormone” ghrelin to stimulate the pituitary gland’s release of endogenous growth hormone (GH).
Key Benefits and Potential Uses
GHRP-2 is primarily researched and utilized in contexts involving growth hormone stimulation, including:
- Diagnostic assessment of growth hormone deficiency (GHD) in children and adults (approved in some regions like Japan under the brand GHRP Kaken 100 for diagnostic purposes).
- Supporting increased GH and IGF-1 levels, which may contribute to improved muscle protein synthesis, enhanced recovery, and better body composition.
- Potential applications in promoting lean muscle growth, fat metabolism, and recovery from intense physical activity or injury.
- Studies in animal models and limited human trials suggest benefits for growth performance in cases of growth retardation, increased appetite/food intake, and support for metabolic health.
- Often explored in regenerative and performance wellness settings to encourage natural GH pulsatile release rather than exogenous hormone administration.
It works through multiple mechanisms:
- Binds to ghrelin receptors in the pituitary and hypothalamus to trigger GH secretion in a pulsatile, more physiological manner.
- May inhibit somatostatin (a GH suppressor) while amplifying GH-releasing pathways, including calcium-dependent signaling.
- Increases hunger and food intake (orexigenic effect), which can support caloric needs during muscle-building or recovery phases (though less pronounced than with GHRP-6 in some comparisons).
Administration Options
GHRP-2 is typically available as a lyophilized powder for reconstitution and subcutaneous injection (most common in research and wellness use). It has also been studied via intravenous, intranasal, and oral routes. Dosing in research settings often starts low (e.g., 1–3 μg/kg) and may be administered 1–3 times daily, with gradual titration under supervision to assess response and tolerance.
Here are the most common FAQs for GHRP-2 (Pralmorelin):
What Is GHRP-2?
GHRP-2 (also known as Pralmorelin) is a 6-amino-acid synthetic growth hormone (GH) secretagogue (D-Ala-D-BNal-Ala-Trp-D-Phe-Lys-NH2). It’s a second-generation hexapeptide that sits between GHRP-6 and ipamorelin in terms of selectivity. GHRP-2 is FDA-approved in Japan as pralmorelin for diagnosing growth hormone deficiency (GHRP-2 stimulation test), making it the only GHRP with regulatory approval anywhere in the world.[peptidebond]
What Does GHRP-2 Do in the Body?
Primary effects:
-
Strong GH release from anterior pituitary
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Elevates cortisol and prolactin (moderate levels)
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Stimulates appetite (via ghrelin-receptor activation)
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Promotes muscle growth and recovery
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Enhances fat loss
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Improves joint repair
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Boosts metabolism.[swolverine]
How Does GHRP-2 Work?
Mechanism of action:
-
Activates GHS-R1a receptor (growth hormone secretagogue receptor)
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Stimulates GH release from anterior pituitary gland
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Acts as synthetic ghrelin mimetic
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Improved selectivity over GHRP-6 due to D-beta-naphthylalanine residue at position 2
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GHS-R1a activation leads to GH release with less appetite stimulation than GHRP-6.[pmc.ncbi.nlm.nih]
What Are the Benefits of GHRP-2?
Potential benefits:
What Is the Dosage for GHRP-2?
Research protocols:
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Typical dose: 100–200 mcg per injection
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Frequency: 2–3 times daily (cycle: 5 days on, 2 days off)
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Timing: On empty stomach (before meals or between meals)
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Administration: Subcutaneous (SC) or Intravenous (IV) injection
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Cycle: 5-on/2-off (prevents receptor desensitization).[swolverine]
Cycling: Receptor desensitization kicks in within 5 days, so 5-on/2-off cycling is recommended.[peptideschedule]
How Long Does It Take to Work?
Timeline:
-
GH release: Immediate (within minutes)
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Appetite stimulation: Within 30–60 minutes
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Muscle growth: Several weeks of consistent use
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Fat loss: Gradual over weeks
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Full effects: 8–12 weeks.[peptidebond]
What Are the Side Effects of GHRP-2?
Common side effects:
Cortisol increase: ~40% less than GHRP-6 at equipotent GH-releasing doses.[peptidebond]
Is GHRP-2 Safe Long-Term?
Current data:
-
Long-term safety unknown (limited human studies)
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Cortisol and prolactin elevations are typically transient (return to baseline within hours)
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Chronic use may warrant monitoring of these hormones
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Japanese regulatory approval provides safety data foundation for diagnostic use
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Not recommended for recreational use without medical supervision.[peptide-db]
Who Should NOT Use GHRP-2?
Contraindications:
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Cancer or history of cancer
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Active pituitary disorders
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Uncontrolled diabetes
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Pregnancy or breastfeeding
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Children (without medical supervision)
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Recreational use (not for athletic enhancement without medical need).[peptide-db]
Is GHRP-2 FDA-Approved?
In Japan: Yes, approved as pralmorelin for GH deficiency diagnosis (GHRP-2 stimulation test).[peptideprotocolwiki]
In US (FDA): Not approved for any use.[peptidebond]
WADA: Banned under S2 (growth hormone secretagogues).[peptidebond]
Can GHRP-2 Be Stacked with Other Peptides?
Yes. Common stacks:
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GHRP-2 + CJC-1295 (no DAC) — enhanced GH release (best together on empty stomach)
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GHRP-2 + MK-677 — synergistic appetite/GH effects
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GHRP-2 + GHRH analogs — enhanced GH release
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GHRP-2 + IGF-1 LR3 — muscle growth synergy.[swolverine]
How Does GHRP-2 Compare to GHRP-6?
Comparison:
GHRP-2 is more selective and cleaner profile than GHRP-6.[peptidepedia]
How Does GHRP-2 Compare to Ipamorelin?
Comparison:
GHRP-2 is less selective but produces stronger GH pulses than ipamorelin.[peptidepedia]
How Does GHRP-2 Compare to MK-677 (Istradefiline)?
Comparison:
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